08 Apr 2021

LIVE BLOG: R&D response to COVID-19 pandemic

Covid 19 blog

The coronavirus pandemic is disrupting universities and research institutes across the world. But the same institutions are also working very hard to find out how the disease can be stopped and its effects mitigated.

Follow this live blog for the latest updates on how the crisis is impacting research and innovation, and what governments, funders, companies, universities, associations and scientists are doing to stop or cope with the pandemic.

You can read the full archive of this blog here.


The European Commission has put in place what it calls a targeted “transparency and authorisation mechanism”, under which individual member states could stop COVID-19 vaccines being exported outside the EU.

The Commission said the move is an effort “to ensure timely access to COVID-19 vaccines for all EU citizens and to tackle the current lack of transparency of vaccine exports outside the EU.”

President of the European Commission Ursula von der Leyen said, “This transparency and authorisation mechanism is temporary, and we will of course continue to uphold our commitments towards low and middle income countries.”

The measure is limited to vaccines for which the EU has agreed advance purchase agreements, said executive vice president and Commissioner for trade Valdis Dombrovskis. “The aim is to provide greater clarity on vaccine production in the EU and their exports – this transparency has been lacking and is vital at this time.”

The Commission worked “for the best part of the last year” to get advance purchase agreements with vaccine producers, said Commissioner for health Stella Kyriakides. “We gave upfront funding to companies to build the necessary manufacturing capacity to produce vaccines, so deliveries can start as soon as they are authorised. We now need transparency on where the vaccines we secured are going and ensure that they reach our citizens.”

The restriction on export of COVID-19 vaccines outside the EU applies until the end of March 2021.


After delaying its COVID-19 vaccine development plan at the end of last year, French pharma Sanofi is now stepping in to help increase supplies of the Pfizer/BioNTech product that is currently the only vaccine available for use in the EU.

Sanofi will provide BioNTech access to its production infrastructure and from summer 2021 will do late stage manufacturing at its facility in Frankfurt to supply over 125 million doses of COVID-19 vaccine for the EU.

British national Paul Hudson, CEO of Sanofi said, “Although vaccination campaigns have started around the world, the ability to get shots into arms is being limited by lower than expected supplies and delayed approval timelines owing to production shortages. We have made the decision to support BioNTech and Pfizer in manufacturing their COVID-19 vaccine in order to help address global needs, given that we have the technology and facilities to do so.”

Sanofi will continue to develop its COVID-19 vaccine, after phase I/II study showed an immune response comparable to patients who recovered from COVID-19 in adults aged 18 to 49 years, but a low immune response in older adults likely due to an insufficient concentration of the antigen.

It plans to initiate a new phase II study in February, with support from the US Biomedical Advanced Research and Development Authority, to evaluate an improved antigen formulation in order to achieve high-level immune response across all age groups.


French biotech Valneva said it has commenced production of its COVID-19 vaccine candidate in Scotland, after signing a deal with the UK government in September last year.

Production has begun in parallel with the ongoing clinical trials, in order to speed the product to market, if the vaccine is found to be safe and effective.

In September 2020, Nantes-based Valneva announced a major COVID-19 vaccine partnership with the UK government for the supply of up to 190 million doses of its COVID-19 vaccine. If vaccine development is successful, Valneva will supply the UK with 60 million doses in the second half of 2021.

The company announced in January 2021 that it is in advanced discussions with the European Commission for the supply of up to 60 million doses but has yet to sign a formal advance purchase agreement.

The phase I/II clinical study is now fully enrolled and is expected to report initial results in April 2021.

Thomas Lingelbach, CEO of Valneva, said, “Our team in Scotland have done an amazing job to get manufacturing started so quickly. I would like to thank the UK Vaccines Taskforce and the National Institute for Health Research who have played vital roles in the rapid recruitment and enrollment of the volunteers for the clinical study.”


The UK is offering its genomics resources to help countries that lack their own capabilities track variants of the SARS-CoV-2 virus that causes COVID-19.

The New Variant Assessment Platform is intended to provide an early warning of mutations that could increase the virulence of the virus, or reduce the efficacy of vaccines and therapeutics.

Countries will be able to access the platform via the World Health Organisation.

The UK has led the world in tracking the evolution of the SARS-CoV-2 genome in real time through sequencing the virus from COVID-19 patients. It currently sequences samples from 5% of patients, and has contributed half of the sequences in the global database.

The initiative will give an early warning of new variants of concern, said Isabel Oliver, director of Public Health England’s national infection service. “We know that the virus will evolve over time,” she said.

A key example is the B 1.1.7 variant, first identified in the UK in December, which is known to be more transmissible, and which initial data indicate is 30 – 40% more lethal. It has since been picked up in more than 60 countries. Other variants of concern have been identified in South Africa and Brazil.


The EU is threatening to introduce export controls for COVID-19 vaccines in response to a row with AstraZeneca over supplies of its vaccine, following reports that the company is unable to meet previous commitments on deliveries. That is said to be as a result of problems at one of the manufacturing facilities.

As a result, deliveries of the AstraZeneca/Oxford University COVID-19 vaccine to the EU are expected to be 60% less than promised during the first quarter of the year.

“In the future, all companies producing vaccines against COVID-19 in the EU will have to provide early notification whenever they want to export vaccines to third countries,” EU health commissioner Stella Kyriakides said on Monday.

The proposal follows frustration in Brussels over an agreement with AstraZeneca to deliver around 80 million of the 300 million doses the Commission has ordered by the end of March. According to the company, it now expects that amount to be cut to 31 million doses due to "production problems" at a manufacturing site in the European supply chain.

In a statement on Monday, Kyriakides said the company’s explanations for the delay “have not been satisfactory”. A call with AstraZeneca CEO Pascal Soriot was scheduled for Monday evening. 

“This new schedule is not acceptable to the EU,” Kyriakides said. “We want clarity and full transparency. The EU has pre-refinanced the development and production of the vaccine and wants to see the return. The EU wants to know exactly which doses have been produced, where, by AstraZeneca so far, and if or to whom they have been delivered.”

On 8 December, the UK Vaccine Taskforce, set up to procure COVID-19 vaccines, said rather than domestic production, the initial doses of the AstraZeneca vaccine were to be imported into the UK from mainland Europe, to get the vaccination programme off the ground as soon as the vaccine was approved by the UK regulator. That happened on 30 December.

The vaccine is not yet approved by the European Medicines Agency, but its decision is expected before Friday.

Frustration with AstraZeneca is heightened by the EU's slow vaccine rollout. Cheaper and easier to distribute compared to the approved vaccines from Pfizer/BioNtech and Moderna, officials had hoped the AstraZeneca vaccine would give the European rollout a big push.


A COVID-19 vaccine based on technology originally developed by the Pasteur Institute in Paris and taken forward by Vienna-based Themis Bioscience, has been dropped by Merck & Co. Inc.

The US pharma company said the vaccine has failed to demonstrate good enough immune responses in phase I studies in healthy volunteers.

Merck said it is also dropping a second programme it was developing in collaboration with the non-profit organisation, AIDS Vaccine Initiative Inc (IAVI), to develop a COVID-19 vaccine based on the same technology as Merck used in its approved vaccine against Ebola virus.

According to the company, the immune responses to both vaccine candidates were inferior to those seen following natural infection and those reported for other COVID-19 vaccines.

This is a double blow, given Merck’s vaccines development and manufacturing capacity.

Merck announced it was acquiring Themis in May 2020, taking on development of the COVID-19 vaccine, which had previously received funding from CEPI, the Coalition for Epidemic Preparedness Initiative.


As the US re-engages with the World Health Organisation (WHO), it will also be joining WHO’s COVAX and ACT-Accelerator initiatives, set up to spur the development of vaccines and therapies, and to ensure their distribution in poorer countries.

“I am pleased to announce today that the US plans to work multilaterally to respond to and recover from the COVID-19 pandemic,” Anthony Fauci, the new US chief medical officer told a meeting of executive board of WHO this morning.

“President Biden will issue a directive later today which will include the intent of the US to join COVAX and support the ACT-Accelerator to advance multilateral efforts for COVID-19 vaccine, therapeutic, and diagnostic distribution, equitable access, and research and development,” Fauci said.

Fauci also thanked WHO for the way it has responded to the pandemic. “Under trying circumstances, this organisation has rallied the scientific and research and development community to accelerate vaccines, therapies and diagnostics; conducted regular, streamed press briefings that authoritatively track global developments; provided millions of vital supplies from lab reagents to protective gear to health care workers in dozens of countries; and relentlessly worked with nations in their fight against COVID-19,” he said.


The annual Altmetric Top 100, highlighting research and academic commentary published in 2020 that generated significant international online attention and discussion, found – unsurprisingly – that Covid-19 research accounted for roughly 30% of the top 100 papers.

These were spread across many disciplines including biomedicine, built environment and design, and economics.

Virus transmission and face mask protection were among the most heavily discussed topics in the analysis of 87.7 million mentions of 3.4 million papers.

The top articles on Covid-19 include:

  • Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers

  • Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

  • It Is Time to Address Airborne Transmission of Coronavirus Disease 2019 (COVID-19)?

  • Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

  • A modelling framework to assess the likely effectiveness of facemasks in combination with "lock-down" in managing the COVID-19 pandemic


A laboratory study to test if the Pfizer/BioNTech COVID-19 vaccine is capable of protecting against a variant of SARS-CoV-2 first detected in the UK, has found that blood samples from vaccinated people neutralise the virus.

The variant, called B.1.1.7, has ten mutations located in the spike protein against which most COVID-19 vaccines are designed. To test the impact on the effectiveness of their vaccine, researchers at Pfizer/BioNTech genetically engineered a replication-deficient virus with the full set of spike mutations. Sera from blood samples of 16 people who took part in a clinical trial of the vaccine inhibited this pseudovirus in a range said to be biologically equivalent to the effect on the original virus that emerged in Wuhan, China.

BioNTech and Pfizer previously published data from a study that evaluated N501Y, one of the key mutations in the B.1.1.7 variant, which is shared by the South African variant that is also causing concern. That study showed efficient neutralisation of the N501Y mutated virus by sera of individuals who had received the Pfizer/BioNTech COVID-19 vaccine.

The two companies said further studies are needed to monitor their vaccine’s effectiveness in preventing COVID-19 caused by new virus variants. It has not been established what reduction in neutralisation might indicate the need to modify a vaccine, but the underlying technology would enable such adjustment.


Health may be a member state competence and an area where the European Commission has very limited powers and influence, but a review of the EU’s initial contribution to the public health response by the European Court of Auditors shows it diverted €547 million to research on COVID-19 between January and June 2020.

The Commission first committed €10 million Horizon 2020 funding for research on COVID-19 on 31 January 2020, using the provision in its work programme that had already committed this amount in case of a public health emergency.

This funding was increased to €48 million by the end of March to support 18 projects (out of 89 eligible applications) developing vaccines, diagnostics, new treatments and monitoring systems.

The Commission then launched a further call for funding applications in May 2020, with a total budget of €130 million, to support 23 projects.

The Innovative Medicines Initiative, the public private partnership between the Commission and the pharmaceutical industry, also launched a call for funding applications in March. It selected eight projects focusing on diagnostics and treatment development, which will receive in total €117 million, €72 million of which is in grants from the European budget.

Then, in April, the Commission committed another €166 million of funding in April 2020 via the EU business accelerator programme, the European Innovation Council, to 72 companies working on innovative projects related to COVID-19.

Court of auditors graph


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