Ark Therapeutics Group plc is pleased to announce that it has been awarded a grant of up to €0.4 million from Finnish Funding Agency for Technology and Innovation (TEKES) to support the further development of Ark’s proprietary lentiviral vector production technology using baculoviruses (“Baculo-lentiviral”) to achieve the scale and GMP quality required for clinical use. Ark has also been awarded a €0.2 million grant from Finnish governmental organization Centre for Economic Development, Transport and the Environment (ELY-centre) to progress validation work in its GMP3 manufacturing facility in Kuopio.
Ark is also pleased to announce that Nature’s Gene Therapy journal has published in its June issue a paper describing Ark’s latest advances in world leading Baculo-lentiviral vector production technology. This work was conducted by Ark scientists in Kuopio, Finland in collaboration with researchers from the University of Eastern Finland and the IBET institute in Portugal.
Lentivirus can be a highly effective vector for gene therapy applications by virtue of its efficient transduction of both dividing and non-dividing cells, long-term stable transgene expression and low immunogenicity. However, difficulties in plasmid-based production methods have limited its clinical applications. Ark scientists have previously described[ii] Ark’s Baculo-lentiviral production system for lentiviral vector production using adherent cells.
The latest improvements described in the June paper are the adaption of the production of lentiviral vectors to a suspension cell culture system using recombinant baculoviruses delivering all elements required for the latest generation of safe, high titer stocks of non-replicating lentiviral vectors. Effective purification by rapid scaleable ion-exchange chromatography was also demonstrated and produced viruses that were shown to mediate effective transduction in vivo.
Ark’s Baculo-lentiviral system makes large scale lentivirus production much more efficient and cost-effective. The support from TEKES and ELY-centre will enable this technology to be established as a production platform within Ark’s GMP manufacturing facility.
Professor Seppo Ylä-Herttuala, Ark’s Consultant Director of Molecular Medicine and the current President of the European Society of Gene and Cell Therapy, commented: “The TEKES and ELY-centre grants and the Baculo-lentiviral publication further demonstrate Ark’s international reputation as a world-leader in gene-based medicines and its pre-eminence in biotherapeutic and viral based manufacturing founded on Ark’s unrivalled viral manufacturing expertise. We look forward to announcing further progress in this area in due course."
Ark Therapeutics Group plc
Ark Therapeutics Group plc is a specialist healthcare group (the "Group") addressing high value areas of unmet medical need within vascular disease and cancer. These are large and growing markets, where opportunities exist for effective new products to generate significant revenues.
Ark has an early stage pipeline emanating from collaborations with University College, London and the AI Virtanen Institute in Kuopio, Finland, the development of which it intends to progress in collaboration with pharmaceutical and biotech partners.
In addition Ark has the ability to off-set a proportion of its R&D costs and to generate sustainable revenues through the exploitation of its proprietary technology platform, process development, scale-up and manufacturing capabilities on behalf of third parties.
Ark has its origins in businesses established in the mid-1990s by Professor John Martin and Mr Stephen Barker of University College London and Professor Seppo Ylä-Herttuala of the AI Virtanen Institute at the University of Kuopio, Finland, all of whom remain consultants on the Company's research and development programmes.
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