Leeds' Syntopix placing falls short on AIM debut

22 Mar 2006 | News

Syntopix Group plc, a spin-out from the University of Leeds, raised a third less than it expected from a placing of shares to institutional investors. The dermatological drug discovery company started trading on London’s AIM market today.

Syntopix said it had raised £4 million at a placing price of 177 pence per ordinary share, and that its market capitalisation, on admission to AIM, was £10.1 million. In late February the company said it was seeking to raise £6 million from the placing. Today Syntopix said its management was not available for comment. Syntopix shares were last trading on AIM at 181.5 pence.

The company said last month the funds would be used to finance drug development programmes. The company currently has a pipeline of nine drug candidates awaiting pre-clinical and clinical trials in acne and MRSA, or methicillin resistant staphylococcus aureus.

Syntopix is targeting a dermatology market that is estimated to have global annual sales of about $10 billion. The global prescription market for the treatment of acne is about $2 billion and is forecast to rise to $3.3 billion in 2006. The market for the topical treatment and prophylaxis of S. aureus infection and carriage is now approximately $0.5 billion and predicted to increase.

The company said bacterial resistance severely compromises the effectiveness of antibiotics in dermatology both against S. aureus infections/carriage and also against acne bacteria. Existing treatments for acne often have unwanted side effects resulting in poor medication adherence. Syntopix is concentrating on change of use and synergistic combinations of known compounds with well-documented pharmacology and toxicity profiles that are already established as safe for human use, it said on its Web site.

Syntopix was formed in 2003 as a spin-out from the University of Leeds to commercialise the research of two scientific founders, Jon Cove and Anne Eady, into antibiotic resistance and diseases of the skin. IP2IPO Group Plc, which specialises in commercialising technologies developed in university science departments, holds a 16.2 per cent stake in the company through its subsidiary.

KBC Peel Hunt Ltd. is Syntopix's adviser and broker.

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