A light-sensitive drug delivery systems has been developed by scientists at Queen’s University Belfast, which the researchers say will make it possible control, where, when and in what doses drugs are delivered, maximizing their effect and reducing side effects.
Colin P. McCoy and colleagues from the School of Pharmacy have developed devices in which drug molecules are combined with light-activated chemicals. These combinations respond to light, releasing precisely controlled amounts of the drug. Drug release begins when light falls on the device, and lasts only as long as the light continues to shine.
The researchers have proof of principle of the system in the controlled release of three common medications used to treat pain and inflammation, aspirin, ibuprofen and ketoprofen.
McCoy says one potential use would be in the treatment of urinary infections caused by catheters, where the drug is held latently in the catheter, and released when needed using light from a fibre optic. The system could be used for other conditions using a drug implant under the skin for precisely controlled dosing.
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