Method for targeting and measuring efficiency of gene transfer

Research lead

Scientists at the national German metrology institute, Physikalisch-Technische Bundesanstalt (PTB), have developed a highly sensitive method for targeting and measuring the efficiency of gene transfer in the treatment of cardiovascular diseases.

Using magnetic nanoparticles attached to the surface of therapeutic genes it is possible to dramatically increase the efficiency of the gene transfer in comparison to other delivery mechanisms.

The magnetised genes are directed to their target by use of an external magnetic field. The researchers say magnetic nanoparticles can support, or even enable gene transfer under clinically relevant experimental conditions.