The Roslin Institute in Edinburgh is looking for partners to use its preclinical sheep model as a model system for respiratory disease.
The Institute has previously used the model system to evaluate treatments for cystic fibrosis. The capabilities include whole lung and segmental aerosol delivery; anaesthesia; lung function testing; negative pressure ventilation; and bronchoscopy (including bronchial brush biopsy, bronchial biopsy and bronchoalveolar lavage).
In addition, Roslin has a range of supporting laboratory, pathology and ancillary techniques, including lung slice and air liquid interface technologies, and routine and specialised necropsy protocols.
Similar imaging, interventional and assessment strategies as those applied to humans can be used, and the model system can be used to assess aerosol treatments. The models provide the opportunity to study responses at the sub-organ level, thus reducing between-animal variation and reducing the numbers of animals needed.
They are suitable for testing respiratory therapies, including gene therapy and medical devices to be used in the lung, and for improving the understanding of human diseases including asthma, asbestosis and emphysema.
The Roslin Institute is seeking industrial partners who would be interested in collaborating on the Roslin Institute sheep model, for testing their therapies or investigating disease.
For more information, see the project’s page at: http://www.university-technology.com/details/intermediate-models-for-lung-function-and-disease