New assay to identify compounds modulating T-cell and B-cell function

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Researchers at Lausanne University and University Hospital Lausanne have identified an enzyme, MALT-1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1), which is involved in the activation of T-cell and B-cell lymphocytes in the immune system.

They say MALT-1 deficient lymphocytes show impaired antigen receptor-induced activation of NF-kB, (Nuclear Factor-KappaB) resulting in impaired proliferation and cytokine production. In addition, abnormal expression or activity of MALT-1 has been associated with the formation of B-cell lymphomas. Using lymphoma tissue lysates from patients, the researchers have shown that MALT-1 is implicated in this disease.

Based on this, the researchers say targeting the protease activity of MALT-1 could be a useful approach for the treatment of autoimmune or inflammatory diseases, for the prevention of transplant rejection and the treatment of lymphoma.

Additional information is available on request.