Aberdeen: Easy-to-use method for 18-Fluorine labelling of antibody fragments and biotin

Licensing opportunity

Currently, labelling macromolecules with Fluorine-18 (18F) involves a time-consuming multistep procedure. Now, however, researchers at Aberdeen University are developing dendrimers and nanoparticles which can be conjugated to targeting molecules such as antibody fragments for direct 18-F labelling, or to biotin for imaging of cell surface molecules that have been pre-labelled with avidin.

The fluorination conditions are mild (room temperature, aqueous solutions) and produce high labelling efficiency, thus eliminating the need for a purification step. These factors mean that ready-assembled tracers can be fluorinated in a short time period with the potential of a one-step synthesis.

For more information, visit the project’s page at http://www.university-technology.com/details/general-18f-labelling-method-for-fragment-antibodies-and-biotin