ETH: Label-free detection of molecular binding to surfaces

03 Jun 2008 | News

Licensing opportunity

ETH-Zürich is looking to license its Imaging Adsorption Sensor (IAS). The technology is a highly sensitive detector that monitors molecular binding to surfaces and can be applied to drug screening, diagnostics and microchip manufacturing.

The IAS sensing platform is an optical setup that combines a white-light source, two Fabry-Perot thin film interferometers and a charge-coupled device (CCD) detector. The sensor is exposed to a gas or liquid medium in a small flow cell designed for multiplexed fluid exchange.

The technology provides real-time imaging of molecular adsorption on the sensor surface, producing a grey level image detectable by eye. A photometric calibration system quantifies film thickness or adsorbed mass.

The technology can be integrated to microscopes and optical fibres, or simply used as a standalone portable device. It is most effective when combined with surface specific sensors and has increased sensitivity over a large range of film thickness (0.1 nanometres to 50 micrometres) particularly within gaseous media.

ETH says its sensor technology is disposable, wearable and can easily be applied to medical diagnostics, biotechnology and process monitoring.


Never miss an update from Science|Business:   Newsletter sign-up