Dr. Dirk Daelemans and his colleagues at the Rega Institute have done pioneering work in the area of nuclear export modulation, particularly in their roles in viral replication. Dr. Daelemans said, “We are very pleased to be working with the team at Karyopharm, as they are in a leading position to move our combined portfolio of compounds into development for the treatment of human diseases.” Sharon Shacham, PhD, MBA, Karyopharm’s CSO and Head of R&D, commented “This collaboration with the Rega Institute, one of the world’s leaders in elucidation of mechanism of action of biologically active compounds, further strengthens our research and development platform dedicated to bringing the first nuclear export inhibitors to the clinic for cancer and other disorders.” It is anticipated that the collaboration will discover novel CRM1 inhibitors, beyond those already patented by Karyopharm.
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